Mid-pregnancy, perinatal, and neonatal reproductive endocrinology: a prospective cohort study in twins and singleton control subjects

摘要: Objective To answer the questions: Are perinatal reproductive hormone profiles different in case of a twin compared with singleton pregnancy? endocrine girls influenced by their male co-twin and vice versa? Design Prospective cohort study from January 2004 to October 2009. Setting Not applicable. Patient(s) A total 204 mothers twins 248 control subjects, aged >18 years, pregnant or no disease malignancy. Intervention(s) Blood samples were collected at mid-gestation mother delivery umbilical cords. Estrogens, androgens, sex hormone-binding globulin, progesterone, gonadotropins measured. Main Outcome Measure(s) Hormonal between singletons twins, types opposite-sex same-sex twins. Result(s) Estrogen progesterone concentrations higher singletons, but babies had lower estrogen birth. Opposite-sex did not have androgens cord blood girls. Boys an luteinizing dizygotic boys brother as co-twin. Conclusion(s) Children are overexposed steroids time birth, despite mothers, opposite do show androgenic influences The female may influence hypothalamic-pituitary-testicular axis her via central inhibition.