Synergistic interaction between atovaquone and retinol in Plasmodium falciparum in vitro.

摘要: The study has been conducted with the objective of assessing blood schizontocidal activities atovaquone (ATO), retinol (RET) and combinations both (ATO-RET) at set concentrations corresponding to 50th, 65th 80th percentile physiological serum levels. in vitro tests followed WHO standard protocol Mark II for measuring inhibition schizont maturation Plasmodium falciparum. Valid results all 5 test lines were obtained 26 fresh parasite isolates from northwestern Thailand, an area affected by multidrug-resistance. EC50 values atovaquone, ATO ATO-RET low, medium high 3.1 nM, 561.8nM, 0.85 0.73 nM 0.45 respectively, EC90 33.7 9338.6 25.31 8.89 5.42 nM. geometric mean cut-off alone 282.5nM, 79.0 38.7 23.7 respectively. These those Berenbaum analysis based on fractional inhibitory indicate synergistic pharmacodynamic interaction between retinol, a phenomenon suggesting that antimalarial activity could be enhanced supplementation retinol.