A TG-repeat polymorphism in the 5 -noncoding region of the goat growth hormone receptor gene and search for its association with milk production traits
作者： Andrzej Maj , Małgorzata Korczak , Emilia Bagnicka , Lech Zwierzchowski , Mariusz Pierzchała
DOI: 10.1016/J.SMALLRUMRES.2005.11.007
关键词: Gene polymorphism 、 Breed 、 Allele 、 Growth hormone receptor 、 Locus (genetics) 、 Genetics 、 Loss of heterozygosity 、 Somatic cell count 、 Genotype 、 Biology
摘要: Abstract A variable TG-repeat polymorphism was found in the goat growth hormone receptor (GHR) gene 5′-noncoding region. In total 235 goats belonging to two dairy breeds were genotyped, 10 alleles of GHR detected. The length repeat region variants (alleles) from 305 346 bp. Among identified, eight occurred homozygous systems. frequency genotypes 0.25 for Polish White Improved breed and 0.28 Fawn breed. mean heterozygosity (H) polymorphic content coefficients (PIC) at this locus similar both breeds. association studied with milk production traits 157 using REML method repeatability, multi-traits Animal Test-Day Model. No associations traits—milk yield major components (fat, protein, lactose). Also, no effect shown genotype on somatic cell count (SCC).
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sci-hub.se 参考文章(22)
C S Hale, W O Herring, H Shibuya, M C Lucy, D B Lubahn, D H Keisler, G S Johnson, Decreased growth in Angus steers with a short TG-microsatellite allele in the P1 promoter of the growth hormone receptor gene. Journal of Animal Science. ,vol. 78, pp. 2099- 2104 ,(2000) , 10.2527/2000.7882099X
D Botstein, R W Davis, R L White, M Skolnick, Construction of a genetic linkage map in man using restriction fragment length polymorphisms. American Journal of Human Genetics. ,vol. 32, pp. 314- 331 ,(1980)
John V. O'Mahoney, Malcolm R. Brandon, Timothy E. Adams, Identification of a liver-specific promoter for the ovine growth hormone receptor Molecular and Cellular Endocrinology. ,vol. 101, pp. 129- 139 ,(1994) , 10.1016/0303-7207(94)90227-5
SE Aggrey, J Yao, MP Sabour, CY Lin, D Zadworny, JF Hayes, U Kuhnlein, Markers within the regulatory region of the growth hormone receptor gene and their association with milk-related traits in Holsteins Journal of Heredity. ,vol. 90, pp. 148- 151 ,(1999) , 10.1093/JHERED/90.1.148
Roman I. Pekhletsky, Boris K. Chernov, Peter M. Rubtsov, Variants of the 5'-untranslated sequence of human growth hormone receptor mRNA. Molecular and Cellular Endocrinology. ,vol. 90, pp. 103- 109 ,(1992) , 10.1016/0303-7207(92)90107-H
Anne Kettunen, Esa A. Mäntysaari, Jukka Pösö, Estimation of genetic parameters for daily milk yield of primiparous Ayrshire cows by random regression test-day models Livestock Production Science. ,vol. 66, pp. 251- 261 ,(2000) , 10.1016/S0301-6226(00)00166-4
Jacek Majewski, Jurg Ott, GT repeats are associated with recombination on human chromosome 22. Genome Research. ,vol. 10, pp. 1108- 1114 ,(2000) , 10.1101/GR.10.8.1108
Tao Zhu, Eyleen L.K Goh, Ralph Graichen, Ling Ling, Peter E Lobie, Signal transduction via the growth hormone receptor Cellular Signalling. ,vol. 13, pp. 599- 616 ,(2001) , 10.1016/S0898-6568(01)00186-3
N Kanai, T Fujii, K Saito, T Tokoyama, Rapid and simple method for preparation of genomic DNA from easily obtainable clotted blood. Journal of Clinical Pathology. ,vol. 47, pp. 1043- 1044 ,(1994) , 10.1136/JCP.47.11.1043
Honglin Jiang, Matthew C Lucy, Variants of the 5'-untranslated region of the bovine growth hormone receptor mRNA: isolation, expression and effects on translational efficiency. Gene. ,vol. 265, pp. 45- 53 ,(2001) , 10.1016/S0378-1119(01)00356-0