Impairment of hepatic transport processes in perfused rat liver by the specific CCK receptor antagonist loxiglumide
作者： Karlheinz Beckh , Anja Dirks , Irmtraut Koop , Herbert Koop , Guido Adler
关键词: Cholecystokinin 、 Cholecystokinin receptor 、 Taurocholic acid 、 Receptor antagonist 、 Leukotriene 、 Antagonist 、 Chemistry 、 Leukotriene D4 、 Internal medicine 、 Endocrinology 、 Proglumide
摘要: The specific cholecystokinin (CCK) receptor antagonist loxiglumide has been used in several human and animal studies to investigate the role of CCK gastrointestinal physiology. In present study, interference this with hepatic transport processes was characterized perfused rat liver. Indocyanine green, an organic dye which is secreted into bile without being metabolized, taken up control experiments at a rate 68.1 ± 7.7%. lowered extraction 0.5 2.6% (P < 0.001). compound diminished CCK-8 from 90.95 2.60% 4.90 1.95% 0.001) gastrin 22.2 1.1% 8.2 1.9% lidocaine, metabolized by cytochrome P450 system, only slightly altered. For leukotrienes taurocholate, rate-limiting step for secretion across canalicular membrane; leukotriene D4 markedly whereas taurocholate inhibited. study demonstrates that various substances, including peptides anions. It did not interfere system. pronounced reduction uptake indocyanine green may be due system these substances
springer.com
sci-hub.se 参考文章(35)
Matthias WETTSTEIN, Wolfgang GEROK, Dieter HAUSSINGER, Metabolism of cysteinyl leukotrienes in non-recirculating rat liver perfusion FEBS Journal. ,vol. 181, pp. 115- 124 ,(1989) , 10.1111/J.1432-1033.1989.TB14701.X
Masaru IWAI, Kurt JUNGERMANN, Mechanism of action of cysteinyl leukotrienes on glucose and lactate balance and on flow in perfused rat liver. Comparison with the effects of sympathetic nerve stimulation and noradrenaline. FEBS Journal. ,vol. 180, pp. 273- 281 ,(1989) , 10.1111/J.1432-1033.1989.TB14644.X
Guido Adler, Christoph Beglinger, Ute Braun, Max Reinshagen, Irmtraut Koop, Anton Schafmayer, Lucio Rovati, Rudolf Arnold, Interaction of the cholinergic system and cholecystokinin in the regulation of endogenous and exogenous stimulation of pancreatic secretion in humans Gastroenterology. ,vol. 100, pp. 537- 543 ,(1991) , 10.1016/0016-5085(91)90227-C
M A Shirley, R C Murphy, Metabolism of leukotriene B4 in isolated rat hepatocytes. Involvement of 2,4-dienoyl-coenzyme A reductase in leukotriene B4 metabolism. Journal of Biological Chemistry. ,vol. 265, pp. 16288- 16295 ,(1990) , 10.1016/S0021-9258(17)46220-X
C Klünemann, T Ishikawa, D Keppler, M Müller, T Schaub, ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates. Journal of Biological Chemistry. ,vol. 265, pp. 19279- 19286 ,(1990) , 10.1016/S0021-9258(17)30655-5
K. Beckh, R. Göke, W. Ruff, I. Koop, R. Arnold, G. Adler, CCK receptor antagonist loxiglumide alters uptake of CCK in perfused liver and pancreatic acini of the rat. Digestion. ,vol. 48, pp. 98- 103 ,(1991) , 10.1159/000200679
Dietrich Keppler, Wolfgang Hagmann, Stephan Rapp, Claudio Denzlinger, Herbert K. Koch, The relation of leukotrienes to liver injury Hepatology. ,vol. 5, pp. 883- 891 ,(1985) , 10.1002/HEP.1840050530
Herbert Krell, Eberhard Dietze, Hemodynamic and metabolic responses to leukotriene C4 in isolated perfused rat liver Hepatology. ,vol. 10, pp. 300- 305 ,(1989) , 10.1002/HEP.1840100308
K. Ziegler, M. Frimmer, H. Kessler, I. Damm, V. Eiermann, S. Koll, J. Zarbock, Modified somatostatins as inhibitors of a multispecific transport system for bile acids and phallotoxins in isolated hepatocytes Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. ,vol. 845, pp. 86- 93 ,(1985) , 10.1016/0167-4889(85)90058-8
William G. M. Hardison, Victor L. Heasley, Dale F. Shellhamer, Specificity of the hepatocyte Na(+)-dependent taurocholate transporter: influence of side chain length and charge. Hepatology. ,vol. 13, pp. 68- 72 ,(1991) , 10.1002/HEP.1840130111