Chest wall Ewing sarcoma: a population-based analysis

摘要: Abstract Background The globally low incidence of pediatric chest wall Ewing sarcoma (CWES) has limited prior studies this disease to mostly small, single-institution reviews. Our objective was assess incidence, demographics, treatment patterns, and long-term survival through a population-based analysis. Materials methods Surveillance, Epidemiology, End Results database used identify patients aged 0-21 y diagnosed with CWES from 1973 2011. Patients were grouped by decade changes in patterns outcomes. effects clinical, demographic, variables on overall (OS) assessed the computation Kaplan–Meier curves log-rank test, Cox proportional hazard regression for multivariable A total 193 histologically confirmed identified. more common men (61%), whites (92%), 11- 17-y olds (49%). It metastatic at presentation 37% patients. When approximately decade, 10-y OS improved progressively 38% 1973-1979 65% 2000-2011 (P = 0.033). use radiation decreased 84% earliest period 40% most recent, whereas proportion receiving surgery increased 75% 85%. controlling covariates analysis, male found have higher mortality than female (hazard ratio: 2.4; confidence interval: 1.4, 4.4; P = 0.0028). Conclusions This analysis demonstrated an impressive trend improving OS, increasing decreasing therapy. study gender difference CWES, females having better prognosis. presence is very important prognostic factor illness.