The human gutome: nutrigenomics of the host-microbiome interactions.
作者： Dimiter V Dimitrov , None
关键词: Computational biology 、 Microbiome 、 Systems biology 、 Metagenomics 、 Biomedicine 、 Population health 、 Nutrigenomics 、 Biotechnology 、 Gut flora 、 Biology 、 Context (language use)
摘要: Demonstrating the importance of gut microbiota in human health and well-being represents a major transformational task both medical nutritional research. Owing to high-throughput -omics methodologies, complexity, evolution with age, individual nature microflora have been more thoroughly investigated. The balance between this complex community bacteria, food nutrients, intestinal genomic physiological milieu is increasingly recognized as contributor disease. This article discusses "gutome," that is, systems biology microbiome host-microbiome interactions. We examine novel ways which study gutome, nutrigenomics generally, can translational impacts 21st century practice biomedicine. describe clinical context experimental well data-driven process-driven approaches are being utilized underscore pivotal gutome common platform for sharing data emerging field integrated metagenomics pathophysiology. vision needs be articulated manner recognizes omics biotechnology nuances science effectively inform population public policy, vice versa.
liebertonline.com参考文章(70)
Michael de Vrese, J. Schrezenmeir, Probiotics, Prebiotics, and Synbiotics Advances in Biochemical Engineering \/ Biotechnology. ,vol. 111, pp. 1- 66 ,(2008) , 10.1007/10_2008_097
Andrew Shreiner, Gary B. Huffnagle, Mairi C. Noverr, The “Microflora Hypothesis” of Allergic Disease Advances in Experimental Medicine and Biology. ,vol. 635, pp. 113- 134 ,(2008) , 10.1007/978-0-387-09550-9_10
Michael Müller, Sander Kersten, Nutrigenomics: goals and strategies Nature Reviews Genetics. ,vol. 4, pp. 315- 322 ,(2003) , 10.1038/NRG1047
Agathe Gelot, Nicolas Barnich, Christel Neut, Laurent Dubuquoy, Caroline Dubuquoy, Emilie Merour, Karen Geboes, Mathias Chamaillard, Arthur Ouwehand, Greg Leyer, Didier Carcano, Jean-Frédéric Colombel, Denis Ardid, Pierre Desreumaux, Christel Rousseaux, Xavier Thuru, Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors. Nature Medicine. ,vol. 13, pp. 35- 37 ,(2007) , 10.1038/NM1521
John C. Lieske, David S. Goldfarb, Claudio De Simone, Cynthia Regnier, Use of a probioitic to decrease enteric hyperoxaluria Kidney International. ,vol. 68, pp. 1244- 1249 ,(2005) , 10.1111/J.1523-1755.2005.00520.X
Kyotaro Kanazawa, Fumio Konishi, Tomotari Mitsuoka, Atsushi Terada, Kikuji Itoh, Seiko Narushima, Megumi Kumemura, Hiroyuki Kimura, Factors Influencing the Development of Sigmoid Colon Cancer Bacteriologic and Biochemical Studies Cancer. ,vol. 77, pp. 1701- 1706 ,(1996) , 10.1002/(SICI)1097-0142(19960415)77:8<1701::AID-CNCR42>3.0.CO;2-0
RB Altman, Direct-to-consumer genetic testing: failure is not an option. Clinical Pharmacology & Therapeutics. ,vol. 86, pp. 15- 17 ,(2009) , 10.1038/CLPT.2009.63
A Drewnowski, M Maillot, N Darmon, Should nutrient profiles be based on 100 g, 100 kcal or serving size? European Journal of Clinical Nutrition. ,vol. 63, pp. 898- 904 ,(2009) , 10.1038/EJCN.2008.53
Jose M. Ordovas, Genotype-phenotype associations: modulation by diet and obesity. Obesity. ,vol. 16, pp. 12- 17 ,(2008) , 10.1038/OBY.2008.515
S. J. F. Cronin, N. T. Nehme, S. Limmer, S. Liegeois, J. A. Pospisilik, D. Schramek, A. Leibbrandt, R. d. M. Simoes, S. Gruber, U. Puc, I. Ebersberger, T. Zoranovic, G. G. Neely, A. von Haeseler, D. Ferrandon, J. M. Penninger, Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Science. ,vol. 325, pp. 340- 343 ,(2009) , 10.1126/SCIENCE.1173164