Wp‡yw enrofloksacyny i florfenikolu podawanych w okresie oko‡olŒgowym na wybrane parametry biochemiczne krwi u kurcz"t* )

作者: K Chrzastek , T Piasecki , A Wieliczko

DOI:

关键词: Adverse effectPharmacologyDiscontinuationUric acidAntibioticsBilirubinFlorfenicolMedicineOral administrationEnrofloxacin

摘要: Summary Enrofloxacin and florfenicol are broad-spectrum, synthetic antibacterials widely used in poultry production. In the present study, effects of enrofoxacin on biochemical parameters newly hatched chicks were investigated following repeated oral administration for 5 consecutive days. Enrofoxacin or was administered once a day, orally at dose rate 10 mg 30 mg/kg b. wt., respectively. The effect antibiotics selected blood (AST, albumins, total proteins, bilirubin, bile acids, uric acid) revealed insignificant changes after discontinuation drug regimen. This study shows that enrofloxacin during days does not induce any adverse when therapeutic

参考文章(20)
Kübba-Heiss A, Hochleithner M, Fuchs A, Hochleithner C, Problems in the interpretation of blood chemistry results in birds Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere. ,vol. 25, pp. 689- ,(1997)
A Anadón, P Bringas, R Fernández, M L Fernàndez-Cruz, M A Martínez, M R Martínez-Larrañaga, M C Fernández, M J Díaz, Pharmacokinetics and residues of enrofloxacin in chickens American Journal of Veterinary Research. ,vol. 56, pp. 501- 506 ,(1995)
弘司 大石, 昌武 村松, 憲一 大前, 祥子 鈴木, 敏雄 高橋, Antimicrobial susceptibility of Actinobacillus (Haemophilus) pleuropneumoniae isolated from pigs with Pleuropneumonia. 日本獸醫學雜誌(The Japanese Journal of Veterinary Science). ,vol. 51, pp. 450- 452 ,(1989)
H. Garcia Ovando, N. Gorla, C. Luders, G. Poloni, C. Errecalde, G. Prieto, I. Puelles, Comparative pharmacokinetics of enrofloxacin and ciprofloxacin in chickens. Journal of Veterinary Pharmacology and Therapeutics. ,vol. 22, pp. 209- 212 ,(1999) , 10.1046/J.1365-2885.1999.00211.X
QIAN-JI GUO, LING-LI HUANG, KE FANG, YU-LIAN WANG, DONG-MEI CHEN, YAN-FEI TAO, MENG-HONG DAI, ZHEN-LI LIU, DA-PENG PENG, ZONG-HUI YUAN, Population pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin in chicken based on retrospective data, incorporating first-pass metabolism. Journal of Veterinary Pharmacology and Therapeutics. ,vol. 33, pp. 84- 94 ,(2010) , 10.1111/J.1365-2885.2009.01106.X
M. Cannon, S. Harford, J. Davies, A comparative study on the inhibitory actions of chloramphenicol, thiamphenicol and some fluorinated derivatives Journal of Antimicrobial Chemotherapy. ,vol. 26, pp. 307- 317 ,(1990) , 10.1093/JAC/26.3.307
R. D. LOBELL, K. J. VARMA, J C JOHNSON, R. A. Sams, D. F. GERKEN, S. M. ASHCRAFT, Pharmacokinetics of florfenicol following intravenous and intramuscular doses to cattle Journal of Veterinary Pharmacology and Therapeutics. ,vol. 17, pp. 253- 258 ,(1994) , 10.1111/J.1365-2885.1994.TB00241.X
M. Grobbel, A. Lübke-Becker, L.H. Wieler, R. Froyman, S. Friederichs, S. Filios, Comparative quantification of the in vitro activity of veterinary fluoroquinolones. Veterinary Microbiology. ,vol. 124, pp. 73- 81 ,(2007) , 10.1016/J.VETMIC.2007.03.017