Mechanotransduction in Cardiac Hypertrophy and Ischemia

摘要: Mechanotransduction is the process by which load-bearing cells sense physical forces, transduce forces into biochemical signals, and generate adaptive or maladaptive responses that lead to alterations in cell structure function. heart not only affects beat-to-beat regulation of cardiac performance, but also profoundly growth, differentiation, survival cellular components comprise human myocardium. Understanding molecular basis for mechanotransduction is, therefore, important our overall understanding growth function during hypertrophy ischemia. Cardiomyocytes rely on several intracellular mechanical load, convert stimuli events affect These sensors include protein within myofilaments Z-discs, integrins other membrane-associated proteins link extracellular matrix cytoskeleton, stretch-activated ion channels. A complex signaling web then transmits signals from mechanosensors nucleus organelles. Ultimately, it hoped new pharmacological genetic approaches targeted specific machinery will be developed translate this wealth basic knowledge therapeutic strategies designed reduce hypertrophy, further protect ischemic myocardium, prevent its transition failure.