Mutations and polymorphisms of estrogens receptors genes and diseases susceptibility
作者： Imen Kallel , Maha Rebai , Ahmed Rebai
DOI: 10.3109/10799893.2012.739624
关键词: Cancer 、 Nuclear receptor 、 Single-nucleotide polymorphism 、 Gene 、 Receptor 、 Biology 、 Transcription factor 、 Microsatellite 、 Estrogen receptor 、 Bioinformatics 、 Genetics
摘要: Background: Estrogen receptors (ER) belong to the super-family of nuclear hormone which act as ligand-regulated transcription factor control a diverse set essentials functions, such growth development, metabolism, and reproduction. Though, involvement these in several diseases including cancer was shown numerous studies.Aim: Here, we reviewed literature report genetic polymorphisms mutations investigated ESR genes (α β) explore their relationship potential role develop some well ER expression status especially cancer.Methods: We searched MEDLINE database with keywords estrogens gene polymorphisms, short tandem repeat (STR) sequences, single-nucleotide (SNPs), risk susceptibility.Results: The functional effects mutations, nucleotide STR on susceptibility multiple diseases, ...
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