Short-Chain Fatty Acids Induce Pro-Inflammatory Cytokine Production Alone and in Combination with Toll-Like Receptor Ligands
作者： Paria Mirmonsef , Mohammad R. Zariffard , Douglas Gilbert , Hadijat Makinde , Alan L. Landay
DOI: 10.1111/J.1600-0897.2011.01089.X
关键词: Bacterial vaginosis 、 Microbiology 、 Human immunodeficiency virus (HIV) 、 Toll-like receptor 、 Cytokine 、 Biology 、 Inflammation 、 Cytokine secretion 、 Reactive oxygen species 、 Anaerobic bacteria
摘要: Problem Short chain fatty acids (SCFAs), produced at relatively high levels by anaerobic bacteria in bacterial vaginosis (BV), are believed to be anti-inflammatory. BV, a common alteration of the genital microbiota associated with increased susceptibility HIV infection, is characterized both pro-inflammatory cytokines and SCFAs. We investigated how SCFAs alone or together TLR-ligands affected cytokine secretion.
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