CT measurements of capillary permeability within nodal masses: a potential technique for assessing the activity of lymphoma
作者： K A Miles , B B Kelley
DOI: 10.1259/BJR.70.829.9059299
关键词: Blood volume 、 Patlak plot 、 Medicine 、 Iopamidol 、 Nuclear medicine 、 Lymphoma 、 Biopsy 、 Vascular permeability 、 Permeability (electromagnetism) 、 Pathology 、 Lymph node
摘要: Analysis of time-attenuation data has enabled CT to measure capillary permeability within the brain and kidney. As yet, such techniques have not been applied nodal masses in patients with lymphoma. Tumour angiogenesis is known produce capillaries that exhibit increased measurements could therefore potentially provide a marker tumour viability. This study aims determine feasibility limitations measurement lymphoma masses. Six biopsy proven studied. Time-attenuation curves from aorta mass were generated single-location dynamic sequence images acquired over 3 min following an intravenous bolus iopamidol. A nuclear medicine processing technique, Patlak analysis, was used calculate blood volume mass. Renal vessel also determined four patients. Median lymph node t...
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