Interactions Between Neural Crest-Derived Cells and Extracellular Microenvironment During Cardiovascular Development

摘要: Organ morphogenesis requires coordinated communications between and within different populations of progenitors. Development the mammalian asymmetric aortic arch artery tree is an excellent model system to study genes mechanisms orchestrating complex inter-tissue interactions during organ morphogenesis. In this system, initially symmetric vascular connecting heart embryonic circulation undergoes remodeling in a highly stereotyped manner. This morphogenetic process essential for separation arterial venous circulations communication cells mesoderm, endoderm, surface ectoderm, neural crest. While number key signals have been identified, means by which these are integrated drive not well understood. One possible signaling various growth factors can be into precise developmental programs via extracellular matrix. review will examine roles matrix proteins mediating factor crest surrounding tissues development cardiac outflow tract arteries.