The impairment of glucogenesis by gram negative infection.
作者： Kathryn F. LaNoue , Arthur D. Mason , Jerl P. Daniels
DOI: 10.1016/0026-0495(68)90019-X
关键词: Gluconeogenesis 、 Pseudomonas aeruginosa 、 Enzyme 、 Internal medicine 、 Biology 、 In vitro 、 Lethal dose 、 Hypoglycemia 、 Metabolism 、 Endocrinology 、 Escherichia coli
摘要: In vitro studies of gluconeogenesis in rat liver tissue have been carried out. The rates glucogenesis slices from rats suffering a Pseudomonas aeruginosa infection and injected with lethal dose Escherichia coli endotoxin measured. content certain key glucogenic enzymes was also measured these animals. specific studied were glucose-6-phosphatase, fructose-1,6-diphosphatase phosphoenol-pyruvate carboxykinase. overall rate shown to be impaired by endotoxemia. activity glucose-6-phoshpatase significantly lower the infected endotoxic animals than controls. other appeared unaffected.
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