Effects of human relaxin on orthodontic tooth movement and periodontal ligaments in rats

摘要: Introduction The rate-limiting step in orthodontic treatment is often the rapidity with which teeth move. Using biological agents to modify rate of tooth movement has been shown be effective animals. Relaxin a hormone present both males and females. Its main action increase turnover fibrous connective tissues. Thus, relaxin might amount through its effect on periodontal ligament (PDL). purpose this study was measure PDL structures. Methods Bilateral appliances designed tip maxillary molars mesially force 40 cN were placed 96 rats. At day 0, animals randomized either or vehicle treatment. Twelve rats each group killed at 2, 4, 7, 9 days after appliance activation. Cephalograms taken placement when killed. Tooth measured cephalometrically relation palatal implants. Fractal analysis visual analog scale assessments used evaluate fiber organization tension sites histologic sections. in-vitro testing for mechanical strength mobility performed by using tissue from an additional 20 that had previously received same treatments 1 3 (n = 5). Results Both groups statistically significant as functions time. However, did not stimulate significantly greater more rapid movement. analyses implied reduced organization. In-vitro indicated mandibular incisors relaxin-treated yield load, strain, stiffness. Moreover, range first increased 130% 170%, over vehicle-treated 1. Conclusions Human does accelerate rats; it can reduce level organization, strength, early time points.