Viral Glycosphingolipids Induce Lytic Infection and Cell Death in Marine Phytoplankton
作者： A. Vardi , B. A. S. Van Mooy , H. F. Fredricks , K. J. Popendorf , J. E. Ossolinski
关键词: Virus 、 Microbiology 、 Lytic cycle 、 Biology 、 Programmed cell death 、 Ecology 、 Coccolithophore 、 Coccolithovirus 、 Sphingolipid 、 Emiliania huxleyi 、 Marine bacteriophage
摘要: Marine viruses that infect phytoplankton are recognized as a major ecological and evolutionary driving force, shaping community structure nutrient cycling in the marine environment. Little is known about signal transduction pathways mediating viral infection. We show glycosphingolipids regulate infection of Emiliania huxleyi, cosmopolitan coccolithophore plays role global carbon cycle. These sphingolipids derive from an unprecedented cluster biosynthetic genes Coccolithovirus genomes, synthesized de novo during lytic infection, enriched virion membranes. Purified induced biochemical hallmarks programmed cell death uninfected host. lipids were detected populations North Atlantic, which highlights their potential biomarkers for oceans.
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