Introducing the pro-coagulant contact system in the numerical assessment of device-related thrombosis
作者： Rodrigo Méndez Rojano , Simon Mendez , Franck Nicoud
DOI: 10.1007/S10237-017-0994-3
关键词: Thrombosis 、 Thrombin 、 Factor XII 、 Thrombus 、 Contact system 、 Current (fluid) 、 Coagulation 、 Platelet activation 、 Biomedical engineering 、 Materials science
摘要: Thrombosis is a major concern in blood-coated medical devices. Contact activation, which the initial part of coagulation cascade device-related thrombosis, not considered current thrombus formation models. In present study, pro-coagulant reactions including contact activation system are coupled with fluid solver order to evaluate potential initiate thrombin production. The biochemical/fluid model applied backward-facing step configuration, flow configuration that frequently appears contrast vivo thrombosis models specific thrombotic zone (injury region) set priori by user reaction, reactive surface boundary condition whole device wall. Simulation results show large concentration regions related recirculation zones without need an knowledge location. numerical align well prone observed experimental reported literature. This approach could complement take into account platelet activity and growth optimize wide range
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sci-hub.se 参考文章(55)
Donghui Zhu, Mathematical modeling of blood coagulation cascade: kinetics of intrinsic and extrinsic pathways in normal and deficient conditions. Blood Coagulation & Fibrinolysis. ,vol. 18, pp. 637- 646 ,(2007) , 10.1097/MBC.0B013E3282A167BB
Kenneth A. Johnson, Roger S. Goody, The Original Michaelis Constant: Translation of the 1913 Michaelis–Menten Paper Biochemistry. ,vol. 50, pp. 8264- 8269 ,(2011) , 10.1021/BI201284U
Kate Gregory, Diran Basmadjian, An analysis of the contact phase of blood coagulation: effects of shear rate and surface are intertwined. Annals of Biomedical Engineering. ,vol. 22, pp. 184- 193 ,(1994) , 10.1007/BF02390376
Rachael Brown, Cheree James, Luke A. Henderson, Vaughan G. Macefield, Autonomic markers of emotional processing: skin sympathetic nerve activity in humans during exposure to emotionally charged images. Frontiers in Physiology. ,vol. 3, pp. 1- 6 ,(2012) , 10.3389/FPHYS.2012.00394
Gaurav Girdhar, Yared Alemu, Michalis Xenos, Jawaad Sheriff, Jolyon Jesty, Shmuel Einav, Danny Bluestein, Design Optimization of a Mechanical Heart Valve for Reducing Valve Thrombogenicity—A Case Study with ATS Valve ASME 2010 Summer Bioengineering Conference, Parts A and B. pp. 277- 278 ,(2010) , 10.1115/SBC2010-19309
J. David Hellums, 1993 Whitaker lecture: Biorheology in thrombosis research Annals of Biomedical Engineering. ,vol. 22, pp. 445- 455 ,(1994) , 10.1007/BF02367081
Aaron L. Fogelson, Continuum Models of Platelet Aggregation: Formulation and Mechanical Properties SIAM Journal on Applied Mathematics. ,vol. 52, pp. 1089- 1110 ,(1992) , 10.1137/0152064
Joshua O. Taylor, Kory P. Witmer, Thomas Neuberger, Brent A. Craven, Richard S. Meyer, Steven Deutsch, Keefe B. Manning, In vitro quantification of time dependent thrombus size using magnetic resonance imaging and computational simulations of thrombus surface shear stresses. Journal of Biomechanical Engineering-transactions of The Asme. ,vol. 136, pp. 071012- ,(2014) , 10.1115/1.4027613
B. F. Armaly, F. Durst, J. C. F. Pereira, B. Schönung, Experimental and Theoretical Investigation of Backward-Facing Step Flow Journal of Fluid Mechanics. ,vol. 127, pp. 473- 496 ,(1983) , 10.1017/S0022112083002839
A. M. Fagan, C. Xiong, M. S. Jasielec, R. J. Bateman, A. M. Goate, T. L. S. Benzinger, B. Ghetti, R. N. Martins, C. L. Masters, R. Mayeux, J. M. Ringman, M. N. Rossor, S. Salloway, P. R. Schofield, R. A. Sperling, D. Marcus, N. J. Cairns, V. D. Buckles, J. H. Ladenson, J. C. Morris, D. M. Holtzman, , Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer's disease. Science Translational Medicine. ,vol. 6, pp. 1- 16 ,(2014) , 10.1126/SCITRANSLMED.3007901