Pyridine-grafted chitosan derivative as an antifungal agent.
作者： Ruixiu Jia , Yunfei Duan , Qiang Fang , Xiangyang Wang , Jianying Huang
DOI: 10.1016/J.FOODCHEM.2015.09.053
关键词: Chitosan 、 Organic chemistry 、 Mycelium 、 Spore germination 、 Chloride 、 Nuclear chemistry 、 Minimum inhibitory concentration 、 Pyridine 、 Chemistry 、 Acute toxicity 、 Botrytis cinerea
摘要: Pyridine moieties were introduced into chitosan by nucleophilic substitution to afford N-(1-carboxybutyl-4-pyridinium) chloride (pyridine chitosan). The resulting derivative was well characterized, and its antifungal activity examined, based on the inhibition of mycelial growth spore germination. results indicated that pyridine exhibited enhanced comparison with pristine chitosan. values minimum inhibitory concentration minimal fungicidal against Fulvia fulva 0.13 mg/ml 1 mg/ml, respectively, while corresponding Botrytis cinerea 4 respectively. Severe morphological changes chitosan-treated B. observed, indicative could damage deform structure fungal hyphae subsequently inhibit strain growth. Non-toxicity demonstrated an acute toxicity study. These are beneficial for assessing potential utilization this exploring new functional agents in food industry.
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