Tumor cell invasiveness in the initial stages of bladder cancer development - A computational study.

摘要: Bladder cancer is one of the most common types cancer, being sixth more frequent in men, and with higher recurrence rates overall treatment costs. We introduce an agent-based computational model urothelium, adopting a Cellular Potts Model approach to describe both healthy urothelium development bladder cancer. focus on identification conditions which cells cross, by mechanical means, basement membrane invade lamina propria. When within tumor grows very constrained environment. These tight imply that layer where initiates greatly determines growth invasiveness. Moreover, we demonstrate how specific properties cells, as their stiffness or adhesion neighboring heavily modulate critical initial moments development. propose these characteristics should be considered therapeutic targets control growth. This article protected copyright. All rights reserved.