Systematic Review and Quality Ranking of Studies of Two Phthalate Metabolites and Anogenital Distance, Bone Health, Inflammation, and Oxidative Stress

摘要: Phthalates are ubiquitous chemical compounds, and two-di-ethyl phthalate (DEP) di-isobutyl (DiBP)-are not currently regulated by the U.S. Congress or European Union. While many reviews of phthalates have been published, none examined bone health, inflammation, oxidative stress; anogenital distance was most recently reviewed in 2014. The objective this paper is to determine if an association exists between mono-ethyl (MEP) mono-isobutyl (MiBP), metabolites DEP DiBP, respectively, four outcomes indicated above. We conducted a literature search PubMed through December 2017 included 29 observational epidemiologic studies published English that assessed MEP and/or MiBP relation one above health humans. Two authors rated each using modified Downs Black (DB) assessment tool; third author settled score disagreements. A single extracted information related study population, exposure outcome assessment, covariates, significant results from article. Ten were identified on distance, five thirteen stress. Score percentages (total points given out total possible points) calculated for study. current research suggests positive two measures stress, 8-hydroxydeoxyguanosine (8-OHdG) 8-isoprostane. potentially associated with 8-OHdG as well, although evidence limited fewer high-quality studies. There does appear be MiBP, it unclear relationships exist these inflammation. Given role stress plays number diseases ubiquity important individuals aware potential sources chemicals.