Genome Effects and Mutational Risk of Radiation

摘要: Ionizing radiation is a part of the natural environment humans are exposed to on Earth. For cells, ionizing only one many sources stress that will be experienced during course lifetime. The primary cellular target DNA. Damage DNA caused by leads mutations in somatic often resulting cancer; germ cells lead hereditary and, theoretically, genetic diseases. In addition, presence damaged nuclear can genomic instability – state result accumulation new even several cell divisions after damage event. Types created each case slightly different and accumulate nuclear, as well mitochondrial genomes. situation further complicated dissimilar effects differing qualities, doses, dose rates. Moreover, identical treatments have specific types under environmental physiological conditions, organisms species, or gender. Despite extensive efforts, there much still not understood about exposure, coming years offer more opportunities explore these areas.