Towards non invasive nerve growth factor therapies for Alzheimer's disease.

摘要: In the past thirty years, nerve growth factor (NGF) has received much attention for its potential role as a therapeutic agent Alzheimer's disease (AD) due to neurotrophic activities on basal forebrain cholinergic neurons. This been renewed by recent findings that provide new causal links between defects in NGF signaling, transport or processing activation of amyloidogenic route and, more generally, AD neurodegeneration. Thus, concept administration human recombinant patients strong rationale, being further validated and ongoing clinical trials with gene-therapy approach. However, widespread application gene cell-therapy strategies delivery seems unpractical, it would be advantageous have non-invasive methods, should also limit adverse effects activating nociceptive responses. review will describe: 1) data from preclinical studies underlying rationale AD; 2) alternative reach adequate concentrations relevant brain areas while preventing onset effects.