The vesicular nucleotide transporter (VNUT) is involved in the extracellular ATP effect on neuronal differentiation
作者： Aida Menéndez-Méndez , Juan Ignacio Díaz-Hernández , M. Teresa Miras-Portugal
DOI: 10.1007/S11302-015-9449-4
关键词: Adenosine triphosphate 、 Extracellular 、 Retinoic acid 、 Purinergic receptor 、 Biology 、 Cellular differentiation 、 Gene silencing 、 Neurite 、 Cell biology 、 Transporter
摘要: Before being released, nucleotides are stored in secretory vesicles through the vesicular nucleotide transporter (VNUT). Once extracellular ATP participates neuronal differentiation processes. Thus, expression of a functional VNUT could be an additional component purinergic system which regulates and axonal elongation. In vitro decreases neuritogenesis N2a cells differentiated by retinoic acid treatment, whereas silencing increases number length neurites these cells. These results highlight role neuritogenic process because this content neurosecretory vesicles.
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