Synthesis and characterization of covalent diphenylalanine nanotube-folic acid conjugates
作者： John J. Castillo , Tomas Rindzevicius , Kaiyu Wu , Michael S. Schmidt , Katarzyna A. Janik
DOI: 10.1007/S11051-014-2525-9
关键词: Combinatorial chemistry 、 Diphenylalanine 、 Nanotube 、 Raman spectroscopy 、 Covalent bond 、 Conjugate 、 Materials science 、 Stereochemistry 、 Amine gas treating 、 Molecule 、 Covalent Interaction
摘要: Herein, we describe the synthesis and characterization of a covalent nanoscale assembly formed between diphenylalanine micro/nanotubes (PNT) folic acid (FA). The conjugate was obtained via chemical functionalization through coupling amine groups PNTs carboxylic FA. surface analysis PNT-FA indicated presence FA aggregates on PNTs. interaction self-assembled further investigated using fluorescence microscopy, Raman surface-enhanced scattering (SERS) spectroscopies. SERS experiments were performed large area silver-capped (diameter 62 nm) silicon nanopillars with an approximate height 400 nm width 200 nm. results showed that procedure preserves molecular structure presented in this study is promising candidate for applications detection diagnosis cancer or tropical diseases such as leishmaniasis carrier nanosystem delivering drugs to malignant tumors overexpress folate receptors.
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