Effect of caffeine on respiratory muscle strength and lung function in prematurely born, ventilated infants
作者： Zainab Kassim , Anne Greenough , Gerrard F. Rafferty
DOI: 10.1007/S00431-009-0961-9
关键词: Functional residual capacity 、 Medicine 、 Mechanical ventilation 、 Respiratory system 、 Respiratory muscle 、 Gestational age 、 Pulmonary compliance 、 Anesthesia 、 Weaning 、 Lung volumes 、 Pediatrics, Perinatology, and Child Health
摘要: The aims of this study were to determine whether caffeine administration increased respiratory muscle function and if was associated with lung improvement in prematurely born infants being weaned from mechanical ventilation. Respiratory assessed by measurement the maximum pressures generated during occlusions at end inspiration (Pemax) expiration (Pimax) volume (functional residual capacity (FRC)) system compliance (CRS) resistance (RRS) 18 a median gestational age 28 (range 24-36) weeks. Measurements made immediately prior (baseline) 6 h later. Six hours after compared baseline, Pemax (p = 0.017), Pimax 0.004), FRC < 0.001), CRS 0.002) RRS 0.004) had significantly improved. Our results suggest that facilitates weaning ventilation improving strength.
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