Edaravone at high concentrations attenuates cognitive dysfunctions induced by abdominal surgery under general anesthesia in aged mice.

摘要: Postoperative cognitive dysfunction (POCD) is a common neurological disease affecting the elderly patients after surgery. Unfortunately, no effective treatment for this has been discovered. Edaravone, clinical-used free radical scavenger, at 3 mg/kg reported to prevent neuroinflammation induced by combination of surgery and lipopolysaccharide in adult rodents. However, we found that edaravone such low concentration could not inhibit POCD aged mice. Instead, 33.2 mg/kg significantly prevented recognition spatial dysfunctions 14 month mice abdominal under general anesthesia with isoflurane. Furthermore, increase tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) interleukin-6 (IL-6) Edaravone also decrease glial fibrillary acidic protein (GFAP) ionized calcium binding adaptor molecule-1 (Iba-1) positive areas hippocampal regions mice, suggesting might surgery-induced over-activation microglia astrocytes. Moreover, substantially increased expression PSD-95 pSer9-glycogen synthase kinase-3β (pSer9-GSK3β) as demonstrated Western blotting assay. activity acetylcholinesterase (AChE) decreased group. All these results suggested high concentrations impairments animals, possibly via attenuation neuroinflammation, synaptic proteins, elevation cholinergic transmission, providing further support be developed POCD.