Glycolipid Antigens in Type I Diabetes Mellitus and Its Long Term Complications
作者： Ramesh C. Nayak
DOI: 10.1007/978-3-642-75133-2_13
关键词: Glycolipid 、 Antigen 、 Pancreas 、 Major histocompatibility complex 、 Beta cell 、 Immunology 、 Sialic acid 、 Cell 、 Autoantibody 、 Medicine
摘要: The accumulated evidence of the past two decades is overwhelmingly in favour an autoimmune mechanism beta cell destruction leading to insulin dependent (Type I diabetes mellitus. This includes association with certain alleles major histocompatibility complex genes, elevated levels circulating activated T-cells, recapitulation destructive process pancreas grafts absence graft rejection, and presence antiislet auto-antibodies (Bottazzo GF, et al. 1974; MacCuish AC, 1974) circulation majority patients. It this latter feature, anti-islet autoantibodies, that can be considered a hallmark diabees. While these autoantibodies have been extensively studied shown present individuals up 10 years prior development overt diabetes. biochemical nature target autoantigen(s) which react still remains elucidated.
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