Effects of a polysaccharide-based multi-ingredient supplement on salivary immunity in non-elite marathon runners

摘要: Extreme exercise may alter the innate immune system. Glycans are involved in several biological processes including system regulation. However, limited data regarding impact of glycan supplementation on immunological parameters after strenuous available. We aimed to determine a standardized polysaccharide-based multi-ingredient supplement, Advanced Ambrotose© complex powder (AA) salivary secretory Immunoglobulin A (sIgA) and pro- anti-inflammatory protein levels before marathon non-elite runners. Forty-one male runners who completed 42.195 km 2016 Barcelona were randomly assigned two study groups. Of them, n = 20 (48%) received AA supplement for 15 days prior race (AA group) n = 21 (52%) did not receive any (non-AA group). Saliva blood samples collected day days end race. Salivary IgA, pro-inflammatory chemokines (Gro-alpha, Gro-beta, MCP-1) proteins (Angiogenin, ACRP, Siglec 5) determined using commercially ELISA kits saliva supernatant. Biochemical parameters, C-reactive protein, cardiac biomarkers, hemogram also evaluated. Marathon experienced decrease sIgA (Gro-alpha Gro-beta) race, while with showed lower (Angiogenin). Gro-alpha Gro-beta group correlated leukocytes platelets. Changes inflammatory chemokines, especially Gro-alfa observed supplemented These findings suggested that have positive effect response exercise.