Epidermal Adrenergic Signal Transduction as Part of the Neuronal Network in the Human Epidermis

摘要: Human keratinocytes have the full capacity for biosynthesis and degradation of catecholamines. Enzymes in this biosynthetic pathway, as well those involved synthesis essential co-factor (6R)L-erythro-5,6,7,8-tetrahydrobiopterin (6-BH4) are expressed producing important hormones norepinephrine epinephrine, which control a high β2-adrenoceptor density on undifferentiated/proliferating expression α1-adrenoceptors melanocytes. Receptor numbers correlate with calcium uptake or release into cell cytosol, influences process differentiation. After differentiation process, enzyme activities, co-factors, densities decrease significantly keratinocytes, suggesting major function signal transduction system regulation homeostasis epidermis. The importance has been followed two distinct skin disorders: (i) vitiligo, (ii) atopic eczema. In vitiligo there is an overproduction 6-BH4 leading to dysregulation catecholamine creased plasma epidermal level associated β2-adrenoceptors differentiating defective both eczema, point mutation gene could alter structure receptor, thereby low receptors peripheral blood lymphocytes. This review summarized adrenoceptor normal healthy epidermis compared lesional patients Journal Investigative Dermatology Symposium Proceedings 2:37–40, 1997