Cytogenetics and Molecular Genetics of Cell Transformation in Vitro by Mutagens/Carcinogens

作者: E. Gebhart

DOI: 10.1007/978-3-642-75599-6_10

关键词: CarcinogenMammalian cellIn vitroGeneticsTransformation (genetics)Molecular biologyBiologyCytogeneticsCellMutagenicity TestMolecular genetics

摘要: Since its detection by Berwald and Sachs (1965) further development Di Paolo his group (Di Paolo/Donovan 1967) mammalian cell transformation has been proposed as an in vitro model test system for the rapid of carcinogenic agents et al. 1971; Heidelberger 1975; Styles 1980; Meyer 1983). A systematic comparison data from those studies with results classic mutagenicity tests revealed a rather high correlation between both fields (e.g., Ennever Rosenkranz 1987). Therefore, have also included protocols testing.

参考文章(137)
Kiviat, Ansell Js, Ross R, Smooth muscle regeneration in the ureter. Electron microscopic and autoradiographic observations. American Journal of Pathology. ,vol. 72, pp. 403- 416 ,(1973)
Elton Stubblefield, Frances E. Arrighi, Potu N. Rao, Genes, Chromosomes, and Neoplasia ,(1981)
Eugene Elmore, J. Carl Barrett, Robert Langenbach, Tumor promoters : biological approaches for mechanistic studies and assay systems Raven Press. ,(1988)
Pearson, Gene transfer and cancer ,(1984)
Thomas J. Slaga, Claudio J. Conti, Andres J. P. Klein-Szanto, Skin tumors : experimental and clinical aspects Raven Press. ,(1989)
Robert A. Weinberg, Oncogenes of spontaneous and chemically induced tumors. Advances in Cancer Research. ,vol. 36, pp. 149- 163 ,(1982) , 10.1016/S0065-230X(08)60424-8
Charles Heidelberger, Chemical Oncogenesis In Culture Advances in Cancer Research. ,vol. 18, pp. 317- 366 ,(1973) , 10.1016/S0065-230X(08)60756-3