作者: E. Gebhart
DOI: 10.1007/978-3-642-75599-6_10
关键词: Carcinogen 、 Mammalian cell 、 In vitro 、 Genetics 、 Transformation (genetics) 、 Molecular biology 、 Biology 、 Cytogenetics 、 Cell 、 Mutagenicity Test 、 Molecular genetics
摘要: Since its detection by Berwald and Sachs (1965) further development Di Paolo his group (Di Paolo/Donovan 1967) mammalian cell transformation has been proposed as an in vitro model test system for the rapid of carcinogenic agents et al. 1971; Heidelberger 1975; Styles 1980; Meyer 1983). A systematic comparison data from those studies with results classic mutagenicity tests revealed a rather high correlation between both fields (e.g., Ennever Rosenkranz 1987). Therefore, have also included protocols testing.