Stereoselective Methods in the Synthesis of Bioactive Oxathiolane and Dioxolane Nucleosides

Ju-Hyung Woo, Hyun-Jeung Shin, Tae-Ho Kim, Sa-Youl Ghim, Lak-Shin Jeong, Jong-Guk Kim, Bang-Ho Song, Lamivudine production via enantioselective deamination by thermostable Bacillus caldolyticus cytidine deaminase Biotechnology Letters. ,vol. 23, pp. 131- 135 ,(2001) , 10.1023/A:1010353502346

Daniel W. Norbeck, Stephen Spanton, Samuel Broder, Hiroaki Mitsuya, (±)-Dioxolane-T ((±)-1-[(2β,4β)-2-(hydroxymethyl)-4-dioxolanyl]thymine): a new 2',3'-dideoxynucleoside prototype with in vitro activity against HIV Tetrahedron Letters. ,vol. 30, pp. 6263- 6266 ,(1989) , 10.1016/S0040-4039(01)93868-7

C.N. Chang, S.L. Doong, J.H. Zhou, J.W. Beach, L.S. Jeong, C.K. Chu, C.H. Tsai, Y.C. Cheng, D Liotta, R Schinazi, Deoxycytidine deaminase-resistant stereoisomer is the active form of (+/-)-2',3'-dideoxy-3'-thiacytidine in the inhibition of hepatitis B virus replication. Journal of Biological Chemistry. ,vol. 267, pp. 13938- 13942 ,(1992) , 10.1016/S0021-9258(19)49660-9

Susan Cox, John Deadman, Justine Southby, Jonathan Coates, Discovery and Development of Apricitabine John Wiley & Sons, Inc.. pp. 103- 116 ,(2011) , 10.1002/9780470929353.CH8

Yung-Chi Cheng, Kristie L. Grove, Uptake and Metabolism of the New Anticancer Compound β-l-(-)-Dioxolane-Cytidine in Human Prostate Carcinoma DU-145 Cells Cancer Research. ,vol. 56, pp. 4187- 4191 ,(1996)

Henriette Gourdeau, Marilyn L Clarke, France Ouellet, Delores Mowles, Milada Selner, Annie Richard, Nola Lee, John R Mackey, James D Young, Jacques Jolivet, Ronald G Lafreniere, Carol E Cass, Mechanisms of Uptake and Resistance to Troxacitabine, a Novel Deoxycytidine Nucleoside Analogue, in Human Leukemic and Solid Tumor Cell Lines Cancer Research. ,vol. 61, pp. 7217- 7224 ,(2001)

David C. Humber, Martin F. Jones, Jeremy J. Payne, Michael V.J. Ramsay, Boulos Zacharie, Haolun Jin, Arshad Siddiqui, Colleen A. Evans, H.L.Allan Tse, Tarek S. Mansour, Expeditious preparation of (−)-2′-deoxy-3′-thiacytidine (3TC) Tetrahedron Letters. ,vol. 33, pp. 4625- 4628 ,(1992) , 10.1016/S0040-4039(00)61330-8

Yuzeng Liang, Ashoke Sharon, Jason P. Grier, Kimberly L. Rapp, Raymond F. Schinazi, Chung K. Chu, 5′-O-Aliphatic and amino acid ester prodrugs of (−)-β-d-(2R,4R)-dioxolane-thymine (DOT): Synthesis, anti-HIV activity, cytotoxicity and stability studies Bioorganic & Medicinal Chemistry. ,vol. 17, pp. 1404- 1409 ,(2009) , 10.1016/J.BMC.2008.10.078

Richard Storer, Ian R. Clemens, Brian Lamont, Stewart A. Noble, Christopher Williamson, Bernard Belleau, The Resolution and Absolute Stereochemistry of the Enantiomers of cis-1-[2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine (BCH189): Equipotent Anti-HIV Agents Nucleosides, Nucleotides & Nucleic Acids. ,vol. 12, pp. 225- 236 ,(1993) , 10.1080/07328319308021208

Raktim Kumar Ghosh, Samhati Mondal Ghosh, Shalini Chawla, Recent advances in antiretroviral drugs. Expert Opinion on Pharmacotherapy. ,vol. 12, pp. 31- 46 ,(2011) , 10.1517/14656566.2010.509345