Asymmetric vinylogous Michael reaction of α,β-unsaturated ketones with γ-butenolide under multifunctional catalysis
作者： Huicai Huang , Feng Yu , Zhichao Jin , Wenjun Li , Wenbin Wu
DOI: 10.1039/C0CC01054E
关键词: Chemistry 、 Michael reaction 、 Organic chemistry 、 Butenolide 、 Catalysis 、 Amine gas treating
摘要: A general and direct organocatalytic asymmetric vinylogous Michael reaction of γ-butenolide with α,β-unsaturated ketones was investigated a multifunctional primary amine salt as catalyst. The enables straightforward access toward synthetically versatile γ-substituted butenolides from simple 2(5H)-furanone satisfactory yields, diastereo- enantioselectivities (up to 30 : 1 dr 95–99% ee).
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