Formation of non-random extrachromosomal elements during development, differentiation and oncogenesis.
作者： Fabien Kuttler , Sabine Mai
DOI: 10.1016/J.SEMCANCER.2006.10.007
关键词: Gene 、 Extrachromosomal DNA 、 Genome instability 、 Biology 、 Genetics 、 Genome 、 Chromatin 、 Gene duplication 、 Telomere 、 Double minute
摘要: Extrachromosomal elements (EEs) were first discovered as minute chromatin bodies [Cox et al. Minute in malignant tumors of childhood. Lancet 1965;62:55-8], and subsequently characterized small circular DNA molecules physically separated from chromosomes. They include episomes, minichromosomes, polydispersed DNAs or double minutes. This review focuses on eukaryotic EEs generated by genome rearrangements under physiological pathological conditions. Some those occur randomly, but others are strictly non-random, highly regulated, involve specific chromosomal locations (V(D)J-recombination, telomere maintenance mechanisms, c-myc deregulation). The multiple mechanisms formation strongly interconnected frequently linked to gene amplification. Identification genes located will undoubtedly allow a better understanding dynamics oncogenic pathways.
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sci-hub.se 参考文章(134)
S. Takeshita, M. Toda, H. Yamagishi, Excision products of the T cell receptor gene support a progressive rearrangement model of the alpha/delta locus. The EMBO Journal. ,vol. 8, pp. 3261- 3270 ,(1989) , 10.1002/J.1460-2075.1989.TB08486.X
C. Taylor, A. Jalava, S. Mai, c-Myc Dependent Initiation of Genomic Instability During Neoplastic Transformation Current Topics in Microbiology and Immunology. ,vol. 224, pp. 201- 207 ,(1997) , 10.1007/978-3-642-60801-8_20
Sabine Mai, Amanda Guffei, Thierry Fest, J. Frederic Mushinski, c-Myc Deregulation Promotes a Complex Network of Genomic Instability Hormonal Carcinogenesis IV. pp. 87- 97 ,(2005) , 10.1007/0-387-23761-5_7
T.I. Kuschak, B.C. Kuschak, G.M. Smith, J.A. Wright, S. Mai, Isolation of extrachromosomal elements by histone immunoprecipitation BioTechniques. ,vol. 30, pp. 1064- 1072 ,(2001) , 10.2144/01305RR05
D. G. Schatz, E. Spanopoulou, Biochemistry of V(D)J Recombination Current Topics in Microbiology and Immunology. ,vol. 290, pp. 49- 85 ,(2005) , 10.1007/3-540-26363-2_4
Todd, KING'S COLLEGE HOSPITAL.: Adipose Deposit in the Muscular Fibrillœ of the Heart ; Inefficient Action of the Organ; Anasarca and Ascites; Death; Autopsy The Lancet. ,vol. 62, pp. 55- 56 ,(1853) , 10.1016/S0140-6736(02)39956-2
Marcella Boveri, Theodor Boveri, The origin of malignant tumors Williams & Wilkins. ,(1929)
Titia de Lange, T-loops and the origin of telomeres Nature Reviews Molecular Cell Biology. ,vol. 5, pp. 323- 329 ,(2004) , 10.1038/NRM1359
A.M. Olovnikov, A theory of marginotomy: The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon Journal of Theoretical Biology. ,vol. 41, pp. 181- 190 ,(1973) , 10.1016/0022-5193(73)90198-7
Nicholas P. Robinson, Stephen D. Bell, Origins of DNA replication in the three domains of life. FEBS Journal. ,vol. 272, pp. 3757- 3766 ,(2005) , 10.1111/J.1742-4658.2005.04768.X