Effects of silybum marianum on patients with chronic hepatitis C

摘要: BACKGROUND: Silymarin derived from silybum marianum (milk thistle), a flowering member of the daisy family, may benefit liver function in people infected with hepatitis C virus. The aims this pilot study were to assess efficacy and safety silymarin on serum virus (HCV) RNA, aminotransferases (ALT, AST) levels, fibrosis well-being patients chronic (CHC). METHODS: This prospective self-controlled trial was conducted March September 2006 at Department Gastroenterology, Isfahan University Medical Sciences, Isfahan, Iran. 55 HCV (10 female 45 male) mean age 31.8 ± 6.4 years (10-67 years) participated . Patients received 24 weeks (630 mg/day). Baseline virological biochemical, (by markers, including YKL–40 Hyaluronic acid), SF-36 questionnaire performed biochemical tests repeated end treatment period. RESULTS: There statistically difference ALT (108.7 86.6 vs 70.3 57.7) before after (p < 0.001). means AST 99.4 139.7 59.7 64.32 differences = 0.004). After treatment, nine found negative HCV-RNA 0.004) significant improvement results markers only group 0.015). Quality life improved significantly CONCLUSIONS: indicated that CHC performing (650 mg/day) for 6 months, titer, AST), hepatic patient’s quality life. More future studies are warranted. KEYWORDS: Hepatitis Virus (HCV), life, Serum Aminotransferases.