Pain Experience of Children with Sickle Cell Disease Who Had Prolonged Hospitalizations for Acute Painful Episodes

作者: Eufemia Jacob , Brigitta U. Mueller

DOI: 10.1111/J.1526-4637.2006.00252.X

关键词: RegimenAnesthesiaSickle cell anemiaDiseaseMedicineMedical recordKetorolacMorphinePatient-controlled analgesiaAnalgesic

摘要: Purpose. Vaso-occlusive episodes account for 79–91% of emergency room visits and 59–68% hospitalizations in patients with sickle cell disease (SCD). There is a growing recognition that acute painful experiences can lead to long-term consequences. The purpose this study was examine pain management children who had prolonged (>10 days) episodes. Methods. Medical records were reviewed examine: 1) intensity ratings; 2) patterns analgesic use patient controlled analgesia (PCA) regimen; 3) differences between short (≤10 episodes. Results. reported high ratings, which continued throughout hospitalization. most frequently used medications morphine delivered using PCA, long-acting morphine, ketorolac. total mean amount administered 1.16 ± 0.84 mg/kg/day. loading basal rates at doses within the lower range recommendation. significantly higher during hospital stays vs days). However, even though stays, maximum on average only 37% prescribed any given day. Conclusion. Pain ratings persistently moderate levels. Research needed investigate regimens would optimal relief minimize negative consequences associated SCD.

参考文章(48)
Theodore Karrison, Christine Cassel, Kristy Woods, Peter Friedmann, Ashok Patel, Mabel Koshy, Hospital utilization patterns and costs for adult sickle cell patients in Illinois Public Health Reports. ,vol. 112, pp. 44- 51 ,(1997)
Lauren Shaiova, David Wallenstein, Outpatient management of sickle cell pain with chronic opioid pharmacotherapy. Journal of The National Medical Association. ,vol. 96, pp. 984- 986 ,(2004)
Lennette J. Benjamin, Gwendolyn I. Swinson, Ronald L. Nagel, Sickle cell anemia day hospital: an approach for the management of uncomplicated painful crises. Blood. ,vol. 95, pp. 1130- 1136 ,(2000) , 10.1182/BLOOD.V95.4.1130.003K03A_1130_1136
K M Foley, R W Houde, Methadone in cancer pain management: individualize dose and titrate to effect. Journal of Clinical Oncology. ,vol. 16, pp. 3213- 3215 ,(1998) , 10.1200/JCO.1998.16.10.3213
SK Ballas, A Delengowski, Pain measurement in hospitalized adults with sickle cell painful episodes. Annals of Clinical and Laboratory Science. ,vol. 23, pp. 358- 361 ,(1993)
C Ripamonti, L Groff, C Brunelli, D Polastri, A Stavrakis, F De Conno, Switching from morphine to oral methadone in treating cancer pain: what is the equianalgesic dose ratio? Journal of Clinical Oncology. ,vol. 16, pp. 3216- 3221 ,(1998) , 10.1200/JCO.1998.16.10.3216
Ardie Pack-Mabien, E. Labbe, D. Herbert, J. Haynes, Nurses' attitudes and practices in sickle cell pain management. Applied Nursing Research. ,vol. 14, pp. 187- 192 ,(2001) , 10.1053/APNR.2001.26783
Sheila J Jacobson, Ernest A Kopecky, Prashant Joshi, Najib Babul, Randomised trial of oral morphine for painful episodes of sickle-cell disease in children The Lancet. ,vol. 350, pp. 1358- 1361 ,(1997) , 10.1016/S0140-6736(97)08462-6
M. S. Gold, Tetrodotoxin-resistant Na+ currents and inflammatory hyperalgesia. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 7645- 7649 ,(1999) , 10.1073/PNAS.96.14.7645
H.J. McQuay, PRE-EMPTIVE ANALGESIA BJA: British Journal of Anaesthesia. ,vol. 69, pp. 1- 3 ,(1992) , 10.1093/BJA/69.1.1