Intercellular Communication in the Mammalian Ovary: Oocytes Carry the Conversation

作者: Martin M Matzuk , Kathleen H Burns , Maria M Viveiros , John J Eppig

DOI: 10.1126/SCIENCE.1071965

关键词: Somatic cellFolliculogenesisHuman fertilizationOogenesisOvaryOocyteBiologyOvulationEndocrinologyOvarian follicleInternal medicineCell biologyMultidisciplinary

摘要: The production of functional female gametes is essential for the propagation all vertebrate species. growth oocytes within ovarian follicles and their development to mature eggs have fascinated biologists centuries, scientists long realized importance follicle's somatic cells in nurturing oogenesis delivering oocyte oviduct by ovulation. Recent studies revealed key roles folliculogenesis established that bidirectional communication between companion an egg competent undergo fertilization embryogenesis. challenge future identify factors participate this mechanisms action.

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