The role of the gut microbiome in mediating neurotoxic outcomes to PCB exposure.
作者： Kavi M. Rude , Ciara E. Keogh , Mélanie G. Gareau
DOI: 10.1016/J.NEURO.2019.08.010
关键词: Neuroscience 、 Pcb exposure 、 Gut microbiome 、 Neurodegeneration 、 Dysbiosis 、 Autism spectrum disorder 、 Disease 、 Early life 、 Microbiome 、 Medicine
摘要: A series of complex physiological processes underlie the development microbiota, gut, and brain in early life, which together communicate via microbiota-gut-brain axis to maintain health homeostasis. Disruption these can lead dysbiosis pathophysiology gut behavioral deficits including depression, anxiety cognitive deficits. Environmental exposures, particularly interfere with impact pathways. This review will focus on role microbiome neurodevelopment neurodegeneration as well impacts environmental neurotoxicant polychlorinated biphenyls (PCBs), given that serves primary exposure route. There exists extensive research importance developing connections autism spectrum disorder (ASD) increasing links being established between Alzheimer's disease (AD) elderly. Finally, we speculate mechanisms through PCBs induce dysregulate physiology brain.
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sci-hub.se 参考文章(112)
Y Zhao, P Dua, WJ Lukiw, Microbial Sources of Amyloid and Relevance to Amyloidogenesis and Alzheimer's Disease (AD). Journal of Alzheimer’s Disease & Parkinsonism. ,vol. 5, pp. 177- 177 ,(2015) , 10.4172/2161-0460.1000177
Daniel Erny, Anna Lena Hrabě de Angelis, Diego Jaitin, Peter Wieghofer, Ori Staszewski, Eyal David, Hadas Keren-Shaul, Tanel Mahlakoiv, Kristin Jakobshagen, Thorsten Buch, Vera Schwierzeck, Olaf Utermöhlen, Eunyoung Chun, Wendy S Garrett, Kathy D McCoy, Andreas Diefenbach, Peter Staeheli, Bärbel Stecher, Ido Amit, Marco Prinz, Host microbiota constantly control maturation and function of microglia in the CNS Nature Neuroscience. ,vol. 18, pp. 965- 977 ,(2015) , 10.1038/NN.4030
Maha Al-Asmakh, Lars Hedin, Microbiota and the control of blood-tissue barriers. Tissue barriers. ,vol. 3, ,(2015) , 10.1080/21688370.2015.1039691
K. M. Neufeld, N. Kang, J. Bienenstock, J. A. Foster, Reduced anxiety‐like behavior and central neurochemical change in germ‐free mice Neurogastroenterology and Motility. ,vol. 23, pp. 255- ,(2011) , 10.1111/J.1365-2982.2010.01620.X
Lidia Strużyńska, Grzegorz Sulkowski, Beata Dąbrowska-Bouta, Aroclor 1254 selectively inhibits expression of glial GLT-1 glutamate transporter in the forebrain of chronically exposed adult rat. Toxicology. ,vol. 300, pp. 12- 18 ,(2012) , 10.1016/J.TOX.2012.05.009
Lesley A. Graff, John R. Walker, Charles N. Bernstein, Depression and anxiety in inflammatory bowel disease: a review of comorbidity and management. Inflammatory Bowel Diseases. ,vol. 15, pp. 1105- 1118 ,(2009) , 10.1002/IBD.20873
Charity Onore, Milo Careaga, Paul Ashwood, The role of immune dysfunction in the pathophysiology of autism. Brain Behavior and Immunity. ,vol. 26, pp. 383- 392 ,(2012) , 10.1016/J.BBI.2011.08.007
An Li, Karl J. Rockne, Neil Sturchio, Wenlu Song, Justin C. Ford, Hua Wei, PCBs in sediments of the Great Lakes--distribution and trends, homolog and chlorine patterns, and in situ degradation. Environmental Pollution. ,vol. 157, pp. 141- 147 ,(2009) , 10.1016/J.ENVPOL.2008.07.014
P D'Eufemia, M Celli, R Finocchiaro, L Pacifico, L Viozzi, M Zaccagnini, E Cardi, O Giardini, Abnormal intestinal permeability in children with autism. Acta Paediatrica. ,vol. 85, pp. 1076- 1079 ,(1996) , 10.1111/J.1651-2227.1996.TB14220.X
Ricardo Fernández-González, Elena Martínez-Carballo, Carmen González-Barreiro, Raquel Rial-Otero, Jesús Simal-Gándara, Distribution of polychlorinated biphenyls in both products and by-products of a mussel shell incinerator facility Environmental Science and Pollution Research. ,vol. 18, pp. 1139- 1146 ,(2011) , 10.1007/S11356-011-0467-7