Inhibition of gene transcription by polyamide DNA-binding ligands
作者： Peter B. Dervan , Eldon E. Baird , Joel M. Gottesfeld , Donald E. Mosier
DOI:
关键词: Binding site 、 Virus 、 DNA sequencing 、 Minor groove 、 Transcription factor 、 Biology 、 Gene 、 Biochemistry 、 DNA 、 Polyamide
摘要: The invention provides polyamides suitable for modulating cellular or viral gene expression by binding to an identified target DNA sequence adjacent the site of a minor groove transcription factor protein. present are useful treatment human infected with virus such as HIV-1. also conditions, cancers, that result from over-expression genes, particularly oncogenes.
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