Synthesis and characterization of novel copper oxide-chitosan nanocomposites for non-enzymatic glucose sensing

摘要: Abstract This work presents an Extreme Biomimetic approach for the development of a novel non-enzymatic electrochemical glucose sensor based on modification glassy carbon electrode (GCE) with CuO-chitosan nanocomposite. The impact synthesis conditions structure formed nanocomposites was analyzed in detail using variety analytical techniques, including scanning electron microscopy (SEM), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR). To investigate electrocatalytic activity towards oxidation to optimize process, modified electrodes (CuO-CS/GCE) were tested by amperometric potentiometric methods CuO-CS CuO-CS_100 Exhibits 20% better than CuO obtained under same process conditions. CuO-CS/GCE displays high sensitivity (503 μA mM cm−2) detection limit (LOD 11 μM), short response time (within 6 s), very good long-term stability reproducibility. Electrochemical measurements confirmed that nanocomposite after 18 h hydrothermal reaction at 100 °C most efficient modifier GCE. These results clearly indicate is promising future application devices used detect biological fluids.