Calicivirus enteritis in an intestinal transplant recipient.

摘要: Protracted diarrhea of uncertain etiology is a significant problem following intestinal transplantation. We report an infant who developed severe secretory 178 days after transplantation that persisted for more than 120 days. Repeated allograft biopsies demonstrated only nonspecific inflammation. Enzyme immunoassay (for rotavirus), culture, and reverse transcription polymerase chain reaction [calicivirus (Norwalk-like virus)] were used to identify the viral infection. A heavy density calicivirus RNA nucleotide sequences (genogroup II, strain Miami Beach) was isolated from jejunal ileal allograft. Following reduction in immunosuppressive therapy, enteritis remitted association with disappearance all sequences. Calicivirus may cause dysfunction transplant recipients.