Einfluss von Vitamin D auf Knochen und Muskel
作者： S. Scharla
DOI: 10.1007/S11428-016-0101-X
关键词: Gynecology 、 Medicine
摘要: Vitamin-D-Metabolismus Vitamin D wird in der Leber die Speicherform 25-Hydroxy-Vitamin umgewandelt. Die weitere Aktivierung zum Hormon 1,25-Dihydroxy-Vitamin (Kalzitriol) findet streng reguliert Niere statt, kann aber auch lokal Zielorganen erfolgen, z. B. Knochenzellen. Effekte auf Muskel und Knochen zahlen zu den klassischen Vitamin-D-Wirkungen. Kalzitriol wirkt am uber nuklearen Vitamin-D-Rezeptor, daneben nichtgenomische Wege. Es steigert Synthese von Muskelproteinen moduliert Differenzierung Muskelzellen.
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