Splicing proofreading at 5′ splice sites by ATPase Prp28p
作者： Fei Yang , Xiu-Ye Wang , Zhi-Min Zhang , Jia Pu , Yu-Jie Fan
DOI: 10.1093/NAR/GKT149
关键词: Intron 、 Protein splicing 、 Gene 、 RNA splicing 、 Exonic splicing enhancer 、 Genetics 、 Proofreading 、 splice 、 Prp24 、 Biology
摘要: Fidelity and efficiency of pre-mRNA splicing are critical for generating functional mRNAs, but how such accuracy in 5' splice site (SS) selection is attained not fully clear. Through a series yeast genetic screens, we isolated alleles prp28 that
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