Protection of mice from infection with Streptococcus pneumoniae by anti-phosphocholine antibody.

摘要: Anti-phosphocholine (PC) antibody mediated protection against many strains of Streptococcus pneumoniae, and hybridoma anti-PC antibodies protected mice from fatal infections with types 1 3 S. pneumoniae. Live 1, 3, 5, 6A, 19F pneumoniae had similar amounts surface PC accessible to antibody. Furthermore, expressing the X-linked immunodeficiency (xid) CBA/N strain were found be more susceptible infection than immunologically normal mice. The only exception these results was type 5 strain, which highly virulent for both xid In addition, we unable protect by using