Helical Irradiation of the Total Skin with Dose Painting to Replace Total Skin Electron Beam Therapy for Therapy-Refractory Cutaneous CD4+ T-Cell Lymphoma

摘要: A 36-year-old woman was diagnosed with a therapy-refractory cutaneous CD4+ T-cell lymphoma, T3N0M0B0, and stage IIB. Helical irradiation of the total skin (HITS) dose painting techniques, 30 Gy in 40 fractions interrupted at 20 one week resting, 4 times per were prescribed. The diving suit dressed whole body to increase superficial using central core complete block (CCCB) technique for reducing internal organ dose. mean doses critical organs head, chest, abdomen 2.1 29.9 Gy, 2.9 8.1 Gy, 3.6 15.7 Gy, respectively. lesions 84.0 cGy. dosage left side pretreated area decreased 57%. tumor regressed progressively without further noduloplaques. During HITS procedure, most toxicity grade I except leukocytopenia 3. No epitheliolysis, phlyctenules, lysis syndrome, fever, vomiting, dyspnea, edema extremities, or diarrhea occurred during treatment. techniques provides precise delivery impressive results, sparing organs, offering limited transient chronic sequelae previously locally irradiated, lymphoma.