Evaluating psoriasis with Psoriasis Area and Severity Index, Psoriasis Global Assessment, and Lattice System Physician's Global Assessment

摘要: Background Reliable assessment of severity in psoriasis is essential to document treatment responses clinical research. The reliability current outcome measures uncertain. Objective To quantify the relative variation commonly used (the Psoriasis Area and Severity Index [PASI] one version Global Assessment [PGA]), a newer measure, Lattice System Physician's (LS-PGA). Methods Physicians who were experienced (53%; 9/17) or inexperienced (47%; 8/17) using PASI PGA evaluated 35 patients with random order twice each rating system. We assessed scoring within (intrarater) among (interrater) physicians. Results PASI, PGA, LS-PGA highly correlated (r>0.8 for all comparisons) had high overall (Cronbach's α>0.9 each). lower intrarater than PASI. 55% higher concordance coefficient between two evaluations did PGA. Interrater was both before after correction measurement error. Experience beneficial reducing scores but not required LS-PGA. Conclusion LS-PGA, which standardized, does require experience, provides discrete word-based intrinsic meaning, reliable measure therapeutic effect psoriasis, would allow comparisons across different trials.