The Viracept-EMS case: impact and outlook.
作者： Vernon E. Walker , Daniel A. Casciano , David J. Tweats
DOI: 10.1016/J.TOXLET.2009.03.027
关键词: Toxicology 、 ANTIRETROVIRAL AGENTS 、 Additional research 、 Computer science 、 Risk assessment 、 Potential impact 、 Risk factor (computing) 、 Risk analysis (engineering)
摘要: This perspective first considers the potential impact of Viracept-EMS case in framework current understanding low-dose effects DNA-reactive chemicals and approaches used to estimate health risks from genotoxins occurring as impurities pharmaceutical products or contaminants environment workplace. It also presents an outlook on nature additional research building upon test assumptions underlying thresholded dose–response relationships establish biologically based risk assessment models lieu default for compounds.
cabdirect.org
elsevier.com
sci-hub.se 参考文章(90)
Lutz Müller, Thomas Singer, EMS in Viracept--the course of events in 2007 and 2008 from the non-clinical safety point of view. Toxicology Letters. ,vol. 190, pp. 243- 247 ,(2009) , 10.1016/J.TOXLET.2009.02.005
R. Goth, M. F. Rajewsky, Persistence of O6-ethylguanine in rat-brain DNA: correlation with nervous system-specific carcinogenesis by ethylnitrosourea. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 71, pp. 639- 643 ,(1974) , 10.1073/PNAS.71.3.639
Philip C. Hanawalt, Controlling the efficiency of excision repair Mutation Research-dna Repair. ,vol. 485, pp. 3- 13 ,(2001) , 10.1016/S0921-8777(00)00071-9
Nagu Keshava, Chao Chen, Paul White, Bob Sonawane, David Bussard, Biomarkers in toxicology and risk assessment: informing critical dose-response relationships by Swenberg et al., 2008. Chemical Research in Toxicology. ,vol. 22, pp. 8- 10 ,(2009) , 10.1021/TX800356T
Grace S.-F. Lee, Karla S. Blonsky, Diane Lee Van On, Elizabeth A. Savage, A.Richard Morgan, R.C. von Borstel, Base alterations in yeast induced by alkylating agents with differing Swain-Scott substrate constants. Journal of Molecular Biology. ,vol. 223, pp. 617- 626 ,(1992) , 10.1016/0022-2836(92)90978-S
M. S. Eller, T. Maeda, C. Magnoni, D. Atwal, B. A. Gilchrest, Enhancement of DNA repair in human skin cells by thymidine dinucleotides: evidence for a p53-mediated mammalian SOS response. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 12627- 12632 ,(1997) , 10.1073/PNAS.94.23.12627
Gil-Ja Jun, Jai-Youl Ro, Myung Hee Kim, Park Gil-Hong, Woon Ki Paik, Peter N Magee, Kim Sangduk, None, Studies on the distribution of O6-methylguanine-DNA methyltransferase in rat. Biochemical Pharmacology. ,vol. 35, pp. 377- 384 ,(1986) , 10.1016/0006-2952(86)90208-X
W P Roos, M Christmann, S T Fraser, B Kaina, Mouse embryonic stem cells are hypersensitive to apoptosis triggered by the DNA damage O 6 -methylguanine due to high E2F1 regulated mismatch repair Cell Death & Differentiation. ,vol. 14, pp. 1422- 1432 ,(2007) , 10.1038/SJ.CDD.4402136
David T. Beranek, Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents. Mutation Research. ,vol. 231, pp. 11- 30 ,(1990) , 10.1016/0027-5107(90)90173-2
Allen G. Schroering, Kandace J. Williams, Rapid induction of chromatin-associated DNA mismatch repair proteins after MNNG treatment DNA Repair. ,vol. 7, pp. 951- 969 ,(2008) , 10.1016/J.DNAREP.2008.03.023