A cohort study of racing performance in Japanese Thoroughbred racehorses using genome information on ECA18.
作者： T. Tozaki , E. W. Hill , K. Hirota , H. Kakoi , H. Gawahara
DOI: 10.1111/J.1365-2052.2011.02201.X
关键词: Biology 、 Animal science 、 Genome 、 Retrospective cohort study 、 Cohort study 、 Single-nucleotide polymorphism 、 Diagnostic marker 、 Genotype 、 Chromosome 18 、 Internal medicine 、 Horse
摘要: Summary Using 1710 Thoroughbred racehorses in Japan, a cohort study was performed to evaluate the influence of genotypes at four single nucleotide polymorphisms (SNPs) on equine chromosome 18 (ECA18), which were associated previous genome-wide association for racing performance with lifetime earnings and rank. In males, both g.65809482T>C g.65868604G>T related rank (P = 0.005). females, (P = 1.76E-6), (P = 6.81E-6) g.66493737C>T (P = 4.42E-5) strongly also (P C, SNPs, or their combinations, may be genetic diagnostic markers indicators such as WRD BRD.
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sci-hub.se 参考文章(24)
J. H. Jones, K. E. Longworth, A. Lindholm, K. E. Conley, R. H. Karas, S. R. Kayar, C. R. Taylor, Oxygen transport during exercise in large mammals. I. Adaptive variation in oxygen demand Journal of Applied Physiology. ,vol. 67, pp. 862- 870 ,(1989) , 10.1152/JAPPL.1989.67.2.862
T. Tozaki, T. Miyake, H. Kakoi, H. Gawahara, S. Sugita, T. Hasegawa, N. Ishida, K. Hirota, Y. Nakano, A genome-wide association study for racing performances in Thoroughbreds clarifies a candidate region near the MSTN gene. Animal Genetics. ,vol. 41, pp. 28- 35 ,(2010) , 10.1111/J.1365-2052.2010.02095.X
M. M. Binns, D. A. Boehler, D. H. Lambert, Identification of the myostatin locus (MSTN) as having a major effect on optimum racing distance in the Thoroughbred horse in the USA Animal Genetics. ,vol. 41, pp. 154- 158 ,(2010) , 10.1111/J.1365-2052.2010.02126.X
Teruaki Tozaki, June Swinburne, Kei-ichi Hirota, Telhisa Hasegawa, Nobushige Ishida, Takashi Tobe, Improved resolution of the comparative horse-human map: investigating markers with in silico and linkage mapping approaches. Gene. ,vol. 392, pp. 181- 186 ,(2007) , 10.1016/J.GENE.2006.12.018
E. P. Cunningham, J. J. Dooley, R. K. Splan, D. G. Bradley, Microsatellite diversity, pedigree relatedness and the contributions of founder lineages to thoroughbred horses. Animal Genetics. ,vol. 32, pp. 360- 364 ,(2001) , 10.1046/J.1365-2052.2001.00785.X
L. E. YOUNG, D. J. MARLIN, C. DEATON, H. BROWN-FELTNER, C. A. ROBERTS, J. L. N. WOOD, Heart size estimated by echocardiography correlates with maximal oxygen uptake Equine Veterinary Journal. ,vol. 34, pp. 467- 471 ,(2010) , 10.1111/J.2042-3306.2002.TB05467.X
June E. Swinburne, Mike Boursnell, Gemma Hill, Louise Pettitt, Twink Allen, Bhanu Chowdhary, Telhisa Hasegawa, Masahiko Kurosawa, Tosso Leeb, Suguru Mashima, James R. Mickelson, Terje Raudsepp, Teruaki Tozaki, Matthew Binns, Single linkage group per chromosome genetic linkage map for the horse, based on two three-generation, full-sibling, crossbred horse reference families Genomics. ,vol. 87, pp. 1- 29 ,(2006) , 10.1016/J.YGENO.2005.09.001
M. A. Bower, M. G. Campana, M. Whitten, C. J. Edwards, H. Jones, E. Barrett, R. Cassidy, R. E. R. Nisbet, E. W. Hill, C. J. Howe, M. Binns, The cosmopolitan maternal heritage of the Thoroughbred racehorse breed shows a significant contribution from British and Irish native mares Biology Letters. ,vol. 7, pp. 316- 320 ,(2011) , 10.1098/RSBL.2010.0800
Luc Grobet, Luis José Royo Martin, Dominique Poncelet, Dimitri Pirottin, Benoit Brouwers, Juliette Riquet, Andreina Schoeberlein, Susana Dunner, François Ménissier, Julio Massabanda, Ruedi Fries, Roger Hanset, Michel Georges, A deletion in the bovine myostatin gene causes the double-muscled phenotype in cattle. Nature Genetics. ,vol. 17, pp. 71- 74 ,(1997) , 10.1038/NG0997-71
S. A. Williamson, R. G. Beilharz, The inheritance of speed, stamina and other racing performance characters in the Australian Thoroughbred Journal of Animal Breeding and Genetics. ,vol. 115, pp. 1- 16 ,(1998) , 10.1111/J.1439-0388.1998.TB00323.X