Two activated stages of microglia and PET imaging of peripheral benzodiazepine receptors with [11C]PK11195 in rats
作者： Fumitaka Ito , Hiroshi Toyama , Gen Kudo , Hiromi Suzuki , Kentaro Hatano
DOI: 10.1007/S12149-009-0339-0
关键词: Medicine 、 Ligand (biochemistry) 、 Microglia 、 In vivo 、 Resting state fMRI 、 Pathology 、 Lipopolysaccharide 、 Pharmacology 、 Inflammation 、 Peripheral 、 GABAA receptor 、 Radiology Nuclear Medicine and imaging 、 General Medicine
摘要: Objective The transition of microglia from the normal resting state to activated is associated with an increased expression peripheral benzodiazepine receptors (PBR). The extent PBR dependent on level microglial activation. A ligand, [11C]PK11195, has been used for imaging activation in vivo. We evaluated whether [11C]PK11195 PET can indicate differences between no treatment and lipopolysaccharide (LPS) a rat artificial injury model brain inflammation.
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