Subthalamic nucleus phase-amplitude coupling correlates with motor impairment in Parkinson's disease.

摘要: Abstract Objective High-amplitude beta band oscillations within the subthalamic nucleus are frequently associated with Parkinson’s disease but it is unclear how they might lead to motor impairments. Here we investigate a likely pathological coupling between phase of and amplitude high-frequency around 300 Hz. Methods We analysed an extensive data set comprising resting-state recordings obtained from deep brain stimulation electrodes in 33 patients before and/or after taking dopaminergic medication. correlated mean values spectral power phase–amplitude severity hemibody bradykinesia/rigidity. In addition, used simultaneously recorded magnetoencephalography look at functional interactions ipsilateral cortex. Results Beta positively impairment. This effect was more pronounced low-beta range, whilst coherence cortex dominant high-beta range. Conclusions speculate that impede pro-kinetic activity patterns when prominent. Furthermore, results provide evidence for subdivision into low high frequencies. Significance Our findings contribute interpretation oscillatory cortico-basal ganglia circuit.