Pathogenesis of fibrostenosing Crohn's disease.

摘要: Crohn's disease (CD) is a chronic inflammatory disease, which could affect any part of the gastrointestinal tract. A severe complication CD fibrosis-associated strictures, can cause bowel obstruction. Unfortunately, there no specific antifibrotic therapy available. More than 80% patients with will have to undergo at least 1 surgery in their life and recurrence strictures after common. Investigations on mechanism fibrostenosing revealed that fibrosis mainly driven by expansion mesenchymal cells including fibroblasts, myofibroblasts, smooth muscle cells. Being exposed pro-fibrotic milieu, these increase secretion extracellular matrix, as well crosslinking enzymes, drive tissue stiffness remodeling. Fibrogenesis become independent inflammation later stages offers unique therapeutic potential. Exciting new evidence suggests cell hyperplasia strong contributor luminal narrowing fibrostenotic CD. Approval drugs other fibrotic diseases, such idiopathic pulmonary fibrosis, targets associated found CD, cadherins or integrins, shed light development novel approaches