Nucleotide excision repair as a marker for susceptibility to tobacco-related cancers: a review of molecular epidemiological studies.

摘要: DNA repair is a complicated biological process consisting of several distinct pathways that play central role in maintaining genomic stability. Research on and cancer risk vital, emerging field recently has seen rapid advances facilitated by the completion Human Genome Project. In this review, we described phenotypic genotypic markers nucleotide excision (NER) have been used molecular epidemiology studies. We summarized population-based studies to date examined association between capacity phenotype genetic polymorphisms NER genes tobacco-related cancers, including cancers lung, head neck, prostate, bladder, breast, esophagus. also included melanoma nonmelanoma skin because individuals with defective NER, such as patients xeroderma pigmentosum (XP) are highly susceptible ultraviolet light (UV)-induced cancers. The published data provide evidence may contribute susceptibility general population. However, many limited terms size study populations. Furthermore, all findings still considered preliminary, assays yet be validated, results need confirmed. Large well-designed warranted assess gene-gene gene-environment interactions ultimately determine, which biomarkers useful for screening high-risk populations primary prevention early detection